Medical devices or materials are expected to deliver their intended functionalities without causing any potential adverse reactions to a patient, ranging from acute to chronic effects to their body including mutagenic effects. That is why evaluation and Biocompatibility for medical devices is very important for assessing the interaction between the device and cells, tissue and body fluids of patients. Biocompatibility testing is designed mainly for protecting the patient from biological risks. The biocompatibility testing procedure follows three steps · Planning In this stage, information about the materials that are used in manufacturing the device is collected, BEP (biological evaluation plan) is also developed for determining the kind of testing which is needed. · Testing This step begins with in vitro screening through cytotoxicity testing. Some other tests such as chemical characterization or extractable leachable testing are also performed prior to in